Here's how to inoculate ourselves against negative ones. Verified by Psychology Today. Inclusive Insight. In general, we know that people tend to respond negatively to individuals who do not adhere to the gender binary —that is, the notion that there are two sexes, male and female, and that whichever sex you are should clearly dictate your gender and gender role behaviors as either a man or a woman. If a person is biologically male but behaves in stereotypically feminine ways, we can call this gender nonconformity within a cisgender individual i.